2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N0390S5
    L-Glutamine-1-13C 159663-16-8 98.0%
    L-Glutamine-1-13C is the 13C-labeled L-Glutamine (HY-N0390). L-Glutamine is an orally active nutritional agent and cellular metabolism regulator. L-Glutamine is taken up in a Na+-dependent manner and targets multiple key molecules including glutaminase, mTORC1, NF-κB, STAT-3 and HIF-1α. L-Glutamine enhances glutaminolytic catabolism, drives the conversion of glutamate to α-ketoglutarate, thereby regulating gene expression, integrating metabolic signals, mediating glutamine flux and maintaining redox homeostasis. L-Glutamine also promotes cell proliferation, osteogenic differentiation and fracture healing, exerts neuroprotective and cardioprotective effects, and inhibits osteoarthritis. L-Glutamine can be applied to research related to osteoporosis, osteoarthritis, ischemic stroke and acute cantharidin-induced cardiotoxicity.
    L-Glutamine-1-13C
  • HY-N0486S3
    L-Leucine-15N 59935-31-8 ≥98.0%
    L-Leucine-15N is the 15N-labeled L-Leucine. L-Leucine is an essential branched-chain amino acid (BCAA), which activates the mTOR signaling pathway.
    L-Leucine-15N
  • HY-W004066
    Ac-Ala-OH 97-69-8 ≥98.0%
    Ac-Ala-OH is an endogenous metabolite. Ac-ALA-OH inhibits APEH. Ac-Ala-OH can be used in breast cancer research.
    Ac-Ala-OH
  • HY-W004305
    Hexadecanal 629-80-1
    Hexadecanal (Palmitaldehyde) , a volatile long-chain aliphatic aldehyde, is emitted from human feces, skin, and breath. The receptor for hexadecanal(OR37B) is highly conserved across mammals. Hexadecanal may exert its effects by modulating functional connectivity between the brain substrates of social appraisal and the brain substrates of aggressive execution. Also, Hexadecanal is confirmed to be highly deterrent to the ant Lasius niger. Hexadecanal is promising for the research of startle responses and aggression
    Hexadecanal
  • HY-W008385
    H-HoArg-OH 156-86-5 ≥98.0%
    H-HoArg-OH, a homologue arginine, is a strong inhibitor of human bone and liver alkaline phosphatase.
    H-HoArg-OH
  • HY-W010380
    Methyl succinate 3878-55-5
    Methyl succinate is a mitochondrial complex II substrate. Methyl succinate can bypass the inhibition of complex I by Metformin (HY-B0627), restore mitochondrial electron transfer, and reduce AMPK phosphorylation. Methyl succinate is capable of protecting MIN6 β-cells and primary rat β-cells from biguanide-induced toxicity and apoptosis in vitro. Methyl succinate can be used in the research of diseases such as diabetes mellitus.
    Methyl succinate
  • HY-W010589
    L-2-Aminobutyric acid 1492-24-6
    L-2-Aminobutyric acid (H-Abu-OH) is a non-proteinogenic amino acid that exists in human tissues and body fluids. L-2-Aminobutyric acid is formed by the transamination of oxobutyric acid. L-2-Aminobutyric acid can serve as a precursor for anticonvulsant and anti-tuberculosis agents and is a key intermediate in the chemical and pharmaceutical industries.
    L-2-Aminobutyric acid
  • HY-W010861
    2'-Deoxycytidine-5'-diphosphate trisodium 151151-32-5 98.73%
    2'-Deoxycytidine-5'-diphosphate (dCDP) trisodium is an endogenous metabolite.
    2'-Deoxycytidine-5'-diphosphate trisodium
  • HY-W014504
    DL-Kynurenine 343-65-7 98.95%
    DL-Kynurenine is a key metabolite in the tryptophan metabolic pathway and can cross the blood-brain barrier. DL-Kynurenine has a bidirectional regulatory effect on neural excitability. DL-Kynurenine can enhance the convulsive and lethal effects caused by strychnine. DL-Kynurenine is the precursor of Kynurenic acid (HY-100806), which is an antagonist at the glycine site of NMDA receptors and can counteract excitatory toxins. DL-Kynurenine can be used for research on neurotoxicity.
    DL-Kynurenine
  • HY-W015466
    Acetylvaline 96-81-1 ≥98.0%
    Acetylvaline is an amino acid derivative belonging to the N-acetylated amino acid family. Acetylvaline can be detected in small quantities in the urine of healthy individuals but shows significantly abnormal excretion in the urine of patients with maple syrup urine disease (MSUD). Acetylvaline can be used to detect MSUD.
    Acetylvaline
  • HY-W015780
    1,4-Dimethoxybenzene 150-78-7 ≥98.0%
    1,4-Dimethoxybenzene is an endogenous metabolite. 1,4-Dimethoxybenzene has an anti-anxiety effect, increasing atherogenic index (AI) levels in rabbits and inducing sedentary behavior. Sedentary behavior may increase blood cholesterol levels and disrupt blood lipids. 1,4-Dimethoxybenzene considers to be not clastogenic in the in vivo micronucleus test.
    1,4-Dimethoxybenzene
  • HY-W017113
    2-Mercaptobenzothiazole 149-30-4
    2-Mercaptobenzothiazole is an activator of the aryl hydrocarbon receptor (AhR), inhibiting thyroid hormone synthesis and dopamine beta-hydroxylase activity. 2-Mercaptobenzothiazole promotes bladder cancer cell invasion by altering the conformation of the AhR ligand binding domain (LBD), activating AhR transcription, and upregulating the mRNA and protein expression of target genes CYP1A1 and CYP1B1. 2-Mercaptobenzothiazole inhibits thyroid peroxidase (TPO) with an IC50 value of 11.5 μM, induces histological changes such as follicular cell hypertrophy in Xenopus laevis tadpoles, delaying metamorphosis. 2-Mercaptobenzothiazole increases chromosomal aberrations and sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells, and enhances carcinogenicity in F344/N rats. 2-Mercaptobenzothiazole inhibits norepinephrine synthesis in mice and completely blocks the conversion of exogenous dopamine to norepinephrine in rat cardiomyocytes.
    2-Mercaptobenzothiazole
  • HY-W020215
    Tricarballylic acid 99-14-9 98.0%
    Tricarballylic acid is an orally active compound that can be produced by rumen microorganisms and has the activity of chelating magnesium. Tricarballylic acid is also a competitive inhibitor of aconitate hydratase, with a Ki value of 0.52 mM. Tricarballylic acid can inhibit the oxidation of acetate in the citric acid cycle and can be used in the research of ruminant tissue metabolism and grass tetany syndrome. In addition, Tricarballylic acid can be used to synthesize specific complexes and produce plasticizers.
    Tricarballylic acid
  • HY-W129161
    Acetyl tetrapeptide-3 827306-88-7 98.86%
    Acetyl tetrapeptide-3 is a synthetic peptide. Acetyl tetrapeptide-3 enhances the adhesion of hair follicles to the scalp but also promotes the development of new hair follicles. Acetyl tetrapeptide-3 stimulates the synthesis of collagen III in hair follicles. Acetyl tetrapeptide-3 combined with Biochanin A (HY-14595) and ginseng extracts, can stimulate dermal papilla extracellular matrix (ECM) proteins by increasing hydroxyproline, Collagen Type 3, and laminin, yielding a significant improvement in hair follicle size and hair anchoring.
    Acetyl tetrapeptide-3
  • HY-W134326
    Polydextrose 68424-04-4
    Polydextrose is an orally active prebiotic. Polydextrose promotes the growth of Pediococcus pentosaceus ATCC 43200. Polydextrose reduces cholesterol and synergistically lowers blood sugar with Sitagliptin (HY-13749). Currently, it is mainly used in the research of diseases such as hyperlipidemia, type 2 diabetes, and postoperative iron deficiency anemia.
    Polydextrose
  • HY-32933
    4-Acetylphenylboronic acid 149104-90-5 ≥98.0%
    4-Acetylphenylboronic acid is a potent inhibitor of carbonic anhydrases II(CA II), with IC50s of 246 μM and 281.40 μM for bovine CA II (bCA II) and human CA II (hCA II). 4-Acetylphenylboronic acid can be obtained via mechanochemistry and solvent evaporation. 4-Acetylphenylboronic acid has a loss of the carbonyl group at 500-550 K.
    4-Acetylphenylboronic acid
  • HY-113254
    13,14-Dihydro-15-keto-PGE2 363-23-5
    13,14-Dihydro-15-keto-PGE2 participates in Bifidobacterium animalis F1-7 to alleviate opioid-induced constipation by 5-HT pathway.
    13,14-Dihydro-15-keto-PGE2
  • HY-15409R
    Empagliflozin (Standard) 864070-44-0 99.94%
    Empagliflozin (Standard) is the analytical standard of Empagliflozin. This product is intended for research and analytical applications. Empagliflozin (BI 107730 is a selective sodium glucose cotransporter-2 (SGLT-2) inhibitor with an IC50 of 3.1 nM for human SGLT-2.
    Empagliflozin (Standard)
  • HY-B0633D
    Hyaluronic acid sodium (MW 200-1560) 9067-32-7 99.41%
    Hyaluronic acid sodium (MW 200-1560) is a biopolymer composed of repeating disaccharide units, with a molecular weight of 200-1560. Hyaluronic acid sodium is a major component of the extracellular matrix (ECM). It is synthesized on the plasma membrane. Hyaluronic acid sodium exerts its effects by binding to receptors CD44 and RHAMM. Hyaluronic acid sodium activates PI3K-Akt signaling. Hyaluronic acid sodium also enhances cell invasion and angiogenesis by promoting or stimulating the binding of proteolytic MMP-9 to the cell surface. Elevated hyaluronic acid levels are associated with tumor cell growth, adhesion, migration, invasion, and angiogenesis in digestive system cancers. Hyaluronic acid sodium is involved in tissue remodeling and rapid cell proliferation in several physiological processes, including embryonic morphogenesis and wound healing. Hyaluronic acid sodium can be used as a regulator of cancer-associated lymphangiogenesis. Hyaluronic acid sodium can be used as a drug delivery carrier for sodium butyrate, enhancing its anti-proliferative activity against breast cancer cell lines. Hyaluronic acid sodium can lubricate the corneal endothelium. Hyaluronic acid sodium can improve tissue hydration and enhance the resistance of cells to mechanical damage. Hyaluronic acid sodium has been conjugated with antibodies to ensure that the active compound continues to exert its effects at the site of inflammation. Hyaluronic acid sodium can be used in research in the fields of osteoarthritis, ophthalmology, cosmetic dermatology, oncology, and liver diseases.
    Hyaluronic acid sodium (MW 200-1560)
  • HY-B1776S
    Spermidine-d6 2514812-10-1
    Spermidine-d6 is the deuterium labeled Spermidine. Spermidine maintains cell membrane stability, increases antioxidant enzymes activities, improving photosystem II (PSII), and relevant gene expression. Spermidine significantly decreases the H2O2 and O2.- contents.
    Spermidine-d6
Cat. No. Product Name / Synonyms Application Reactivity